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DNA Translocation in Nanopores


One of the recent applications of nanopores is the possibility to use them as detectors and even analyzers for (bio)molecules. A hydrodynamic model is established to investigate the translocation velocity of an electrokinetically driven DNA through a nanopore.  There is an electroosmotic flow inside the nanopore and the velocity field inside the nanopore is calculated. The force balance on the DNA is used as an additional condition to determine the translocation velocity. The numerical results compare well with experimental data.

DNA translocation in a cylindrical nanopore

DNA in a Cylindrical Nanopore

Channel modeled as negatively charged cylindrical channel, with length >> radius.
DNA modeled as negatively charged rigid cylinder along channel axis.
Forces on particle – electric field & viscous drag.
DNA motion direction may be with or against the bulk flow.

current drops

Current drops due to individual translocation events.

DNA translocation in a conical nanopore

Flow field inside the nanopore